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These modifications significantly reduce IGF-1 LR3's binding to IGF binding proteins while maintaining high affinity for the IGF-1 receptor, making it a powerful research tool for studying cell proliferation, differentiation, and survival signalling pathways

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by L-cells in the distal small intestine in response to nutrient ingestion

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Bariatric surgery is another effective tool, yet only a fraction of eligible patients undergo it